불소가 발육중인 백서악하선의 Catecholamine에 미치는 영향
정동균, 이상신,
소속 상세정보
정동균 ( Cheong Dong-Kyun ) - 서울대학교 치과대학
이상신 ( Lee Sang-Sin ) - 서울대학교 치과대학
KMID : 0362719740120030155
Abstract
Catecholamine levels were determined in the submandibular glands of new born rats treated with physiologieal saline solution or large doses of sodium fluoride (10mg/kg) for verying periods of time. In control group, catecholamine levels were gradually increased from fifth day of life until twenty-fifth day of life. When fluoride treatment was started on the fifth day after birth and continued daily to the thirty-fifthday of life, decreased catecholamine levels were obsrved on the fifth, through all experiments, and thirth-fifth day. Daily fluoride treatment from the fifteenth through the thirty-fifth day after birth induced the decreased catecholamine levels which were higher than the levels in submandibular glands of rats treated from the fifth day to the thirty-fifth day after birth with NaF. These experiments suggest that fluoride may be affecting catecholamine biosynthetic mechanisms which were duveloping during the fifteenth to twenty-fifth day of life.
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